Bioanalytical Chemistry
- Development of analytical methods (plasma, urine, tissues, milk, etc.)
- Transfer, full or partial validation of methods
- Analytical assays for pharmacokinetic, metabolism and residue studies (parent compounds and metabolites)
Pharmacokinetics
- Bioavailability
- Bioequivalence
- Single and multiple-dose pharmacokinetics
- Linearity
- Dose ranging
- Toxicokinetics
- Pharmacokinetic evaluation of data: compartmental and non-compartmental analysis
Metabolism
- Absorption, Distribution, Metabolism and Elimination (ADME)
- Mass balance / Excretion (14C, 3H & 35S)
- Biliary excretion – Enterohepatic recirculation
- Tissue distribution
- Metabolite profiling and identification
- Dose analysis: Radiochemical purity and specific activity
- In vitro: S9, microsomes, hepatocytes, inductions, inhibition studies, Caco-2 cells)
- Protein binding (ultrafiltration, equilibrium dialysis)
Residues studies
- Residue depletion in food-producing species
Ecotoxicity
- Ecotoxicological studies: Phase I & Phase II
- Degradation studies (manure, slurry, etc.)
- Adsorption desorption studies (soils)
